She aroused the former president’s ire by backing his impeachment following the January 6 Capitol riot.
So he is backing Cheney challenger Harriet Hageman, who has made the journey from being a “never-Trumper”, to a loyal supporter.
“Unlike RINO Liz Cheney, Harriet is all in for America First,” Mr Trump said, adding that Ms Hageman has his endorsement in “replacing the Democrats number one provider of sound bites, Liz Cheney.”
In all, Mr Trump has targeted an estimated 25 “RINOs”, including those who backed his impeachment after January 6.
In Washington State, the former president has endorsed retired Green Beret Joe Kent against Jaime Herrera Butler, who also voted for Mr Trump to be impeached.
Mr Kent has been vocal in supporting those arrested for their involvement in the January 6 riot, which claimed five lives, describing them as “political prisoners”.
It is also a view shared by several current members of Congress including Matt Gaetz of Florida, Paul Gosar of Arizona and Louie Gohmert of Texas.
Other “colourful” characters are on the way. Laura Loomer – who received Mr Trump’s endorsement – won a primary in Florida.
She has been banned from Twitter after describing Islam as a “cancer”, along with a number of other comments.
If his favoured candidates are successful, the Republicans will shift even further to the right after the mid-term elections, boosting the current cohort of right-wingers.